: It reduces both the number and the affinity of Angiotensin II receptors in the adrenal gland, effectively blocking the primary signal for aldosterone production.

Administering insulin and glucose can help drive potassium back into cells.

Not every patient receiving heparin develops dangerous hyperkalemia. The kidneys are remarkably resilient; in a healthy individual, the contralateral kidney or secondary mechanisms can often compensate for temporary aldosterone blockade. The danger arises when "second hits" are present.