While the "Fox River Eight" are the most famous, the show eventually saw even more breakouts from Sona prison in later seasons. But nothing quite matches the tension of that first night, crawling through the pipes, and realizing that the hard part wasn't getting out—it was staying free.

The young, impressionable thief who just wanted to fit in. Tweener was used as a pawn by both the inmates and the guards. His escape was short-lived. He was ultimately caught and met a tragic end, serving as a grim reminder that not everyone was built for life on the run.

Perhaps the most polarizing character in the show's history. T-Bag forced his way into the escape group through manipulation and violence. A predator with a terrifying intellect, T-Bag managed to survive against all odds. His escape led to a long, dark road of crime and survival, making him the character fans loved to hate (and occasionally hated to love).

: An inmate who discovered the hole in the floor. David "Tweener" Apolskis : A young pickpocket.

The reason for it all. Lincoln was on death row for a crime he didn't commit. While Michael was the brains, Lincoln was often the muscle and the moral compass (when he wasn't being framed). His escape was the catalyst for the entire series, and seeing him walk out of those gates was the emotional payoff the audience waited an entire season to see.

In the end, Prison Break was about more than just jumping a wall. It was about how different people react to freedom. For Michael, it was a burden. For T-Bag, it was an opportunity. And for Lincoln and Sucre, it was a second chance.

Michael’s former cellmate who memorized his tattoos and used that leverage to escape. Failed at Fox River: