Try binding the USB device directly to the Wine prefix... Check the udev rules...
A powerful, open-source general-purpose circuit simulator. multisim on linux
"Wine 8.0 should handle this," he reasoned. "It’s just a wrapper." Try binding the USB device directly to the Wine prefix
Multisim relied on a USB dongle (or a software license service) that talked to the local hardware for security. On Linux, the USB passthrough to Wine was notoriously finicky. If the software couldn't 'see' the licensing dongle, it would run in demo mode—useless for a lab of forty students. multisim on linux
Many Linux users ultimately find a new "main character." Since Multisim doesn't officially support them, they move to native Linux champions like: