Itachi's primary death occurs at the climax of his long-awaited confrontation with his younger brother, Sasuke. After an intense battle involving the Susanoo, Amaterasu, and Kirin, Itachi collapses just steps away from Sasuke. Naruto Shippuden Episode 138. Manga Chapter: Chapter 393.
However, his "death" occurs in two distinct phases: his physical passing after the fated battle with Sasuke and his spiritual departure as a reanimated shinobi. 1. The Fated Battle: Physical Death when does itachi die
Itachi dies for the first time during the arc. Anime: Naruto Shippuden Episode 138 , titled " The End Manga: Chapter 393 , titled " My Victory " (found in Volume 43). Itachi's primary death occurs at the climax of
While it appeared Sasuke killed him, Itachi actually succumbed to a terminal illness and exhaustion. He used medicine and sheer willpower to stay alive just long enough to die by Sasuke's hand to make his brother a hero. The Second Death: Reanimation Release Manga Chapter: Chapter 393
Itachi’s death serves as the ultimate narrative "checkmate." If Sasuke had simply lost, the story would have stalled. If Sasuke had killed Itachi in a rage and felt satisfaction, the character would have become a static villain. Instead, Kishimoto crafted a "hollow victory." Sasuke wins, but he is left empty. The object of his hatred is gone, leaving a void that Madara quickly fills with the truth about Itachi’s life. This pivot turns the climax of the battle into the inciting incident for the next arc (the Five Kage Summit/Attack on Konoha).
While the death scene itself is perfect, the aftermath suffers slightly from "Kishimoto Retcons."
Itachi dies during his final battle with his younger brother, Sasuke Uchiha. After a grueling fight that pushes Sasuke to his absolute limit, depleting his chakra and forcing Orochimaru out of him, Itachi succumbs not to Sasuke’s attacks, but to a terminal illness. He manages to poke Sasuke’s forehead one last time—a callback to their childhood—before collapsing dead.